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As approximately 1221% of Caucasians are poor CYP2D6 metabolizers, compared to only 1% of Pacific islanders, this may explain the higher incidence of hepatotoxicity in Western countries [45]

Given the diversity of study designs and outcome measures, we synthesized the findings narratively rather than quantitatively

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Asthma exhibits significant variability in its clinical presentation, underlying pathology, triggers, and response to treatment, posing ongoing challenges for effective treatment and disease management [12]