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Siddiqua TJ, Akhtar E, Haq MA, et al

MGST1 is a redox-sensitive repressor of ferroptosis in pancreatic cancer cells

In addition to inducing fatty liver, HFD also promotes systemic metabolic syndrome with insulin resistance and glucose intolerance

Taken together, SUMOylation as a stress responsive modification is positively correlated with aging in the human brain, potentially linked to the increase demand imposed by age-associated stress