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Effect of soluble ICAM-1 on a Sjgrens syndrome-like phenotype in NOD mice is disease stage dependent

RESULTS: Islets cultured in high glucose concentrations showed a marked increase in basal insulin secretion

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233 Furthermore, similar to the IL-1 neutralizing antibody canakinumab, IL-18 signaling can be antagonized by its specific inhibitor, IL-18 binding protein (IL-18BP)