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For researchers interested in the comparison between tirzepatide and next-generation compounds like retatrutide, which adds a third receptor (GCG), our guide to retatrutide versus semaglutide provides useful context, as does our three-way comparison of semaglutide, tirzepatide, and retatrutide

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Additionally, the expression levels of iron metabolism-related factors indicated significant decreases in FTH1, TF, and TFRC, alongside notable increases in SLC7A11 and GPX4 levels in the thigh muscle tissue of the sh-TXNIP group compared to the sh-NC group (Figure S4H)

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