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No phase III clinical trial has been completed in humans to date the majority of data comes from animal models

The end products of purine metabolism, uric acid, a potent antioxidant, have been reported to be found in decreased levels in MDD 71,72,73 , while lower cerebro-spinal fluid (CSF) levels of hypoxanthine and xanthine, the two metabolites preceding uric acid, have previously been linked with depression 74

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Further, while we observed that the addition of EDTA improved NAC stability and potency from ~ 33 to ~ 85% under accelerated conditions, ideally less than 10% loss with careful evaluation of degradation products would be necessary to further development