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Hepatic copper concentrations are increased in most affected dogs and are typically between 1000 and 2000 g/g dry weight, although values as high as 4700 g/g have been reported.28, 81 The significance of the increased hepatic copper concentration in this breed remains controversial

PMCID: PMC5549431.

Also, 30 studies examined both genders (66.6%), 8 studies (17.7) and 1 study (2.2%) included only males and females, respectively, and 6 studies did not mention the gender of cases

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When administered properly by qualified professionals, NAD+ therapy has an excellent safety profile, and any side effects are typically mild and manageable