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found that in the mouse mode heme oxygenase 1 (HMOX-1), heat induced and regulated by early growth response factor 1 (EGR1), can mediate ferroptosis in KCs and cause liver injury [47]

11 However, the translational impact of these findings is limited, since only 1520% of patients are diagnosed at an early stage of disease

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While these results are promising, clinical trials in humans are needed to find out if NAC can improve PV symptoms

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