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These include 1) congenital pernicious anaemia, where there is a genetic defect in IF synthesis, leading to B12 malabsorption, 2) Imerslund-Grsbeck Syndrome (IGS) caused by mutations in genes encoding cubulin and amnionless , 3) inherited HC or TCII deficiencies, and 4) intracellular cobalamin defects (CblA-CblG defects)

The goal is consistent: deposit the peptide in the subcutaneous fat layer, not in the dermis above or the muscle below

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For treatment of confirmed dietary B12 deficiency , oral cyanocobalamin at doses of 50-150 micrograms daily may be used

Lymphatic massage and manual lymph drainage have been shown to be especially effective in reducing the symptoms of edema