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Small-animal studies describe loss or activation of nitric oxiderelated pathways following peptide exposure, potentially contributing to vascular resilience under stress (1)

J Physiol Pharmacol 66:581590 Soares de Moura R, Rios AA, de Oliveira LF et al (2001) The effects of nitric oxide synthase inhibitors on the sedative effect of clonidine

CPT 64483 is a transforaminal epidural steroid injection delivering medication to the anterolateral epidural space adjacent to a targeted spinal nerve root

Footnotes Edited by: Bernd Rosenkranz, Fundisa African Academy of Medicines Development, South Africa Reviewed by: Kacper Nijakowski, Poznan University of Medical Sciences, Poland Miriam Njoki Karinja, Science for Africa Foundation, Kenya Data availability statement The original contributions presented in the study are included in the article/Supplementary Material, further inquiries can be directed to the corresponding author

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