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Summary: Sermorelin and Ipamorelin are not interchangeable

Janvier S, Sutter ED, Wynendaele E, Spiegeleer BD, Vanhee C, Deconinck E

As the landscape of longevity medicine shifts in 2026, many individuals are moving away from unregulated research chemicals toward medically supervised peptide protocols designed to optimize sleep, body composition, and recovery

For the vast majority of patients, sermorelin side effects are not dangerous

Ipamorelin acts as a ghrelin receptor agonist with selective growth hormone secretion, while tesamorelin is a growth hormone-releasing hormone (GHRH) analog approved for specific lipodystrophy indications