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A meta-analysis of 21 double-blind clinical trials concluded that acetyl-L-carnitine treatment in patients with mild cognitive impairment and mild Alzheimer's disease demonstrated significant efficacy versus placebo in improving cognitive function, particularly in domains of logical intelligence, verbal memory, selective attention, and functional capacity

M.BremerJ.LeightonF.1992Peroxisomal fatty acid oxidation and inhibitors of the mitochondrial carnitine palmitoyltransferase I in isolated rat hepatocytes