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Mol Metab (2017) 6:1395406

[DOI] [PubMed] [Google Scholar] 130.Shimizu H., Kiyohara Y., Kato I., Kitazono T., Tanizaki Y., Kubo M., Ueno H., Ibayashi S., Fujishima M., Iida M

Most patients begin to experience improvements in energy levels and neurological symptoms within one to two weeks, with continued enhancement over months of use