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In addition to downregulation of injury and inflammation-related pathways, GSEA also revealed suppression of adipogenesis-related pathways in the liver of GPR146-deficient mice, suggesting that GPR146 may promote hepatic steatosis via PPAR-mediated transcriptional programs (Fig

Phytochemical constituents Mucuna seeds are known to produce the unusual nonprotein amino acid 3-(3,4 dihydroxyl phenyl)-l-alanine (l-Dopa), a potent neurotransmitter precursor that is, at least in part, believed to be responsible for the toxicity of Mucuna seeds (Cilia et al

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or when R G is R 2 , R G is C 1 -C 6 alkyl Het, Het or C 1 -C 5 alkyl wherein Het is bonded via C