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Emerging evidence suggests a bidirectional relationship between gut health and brain function, often referred to as the gut-brain axis. Intestinal I/R injury, as a form of acute gut stress, has been implicated in triggering systemic inflammatory responses that extend beyond the gut, to impact distant organs, including the brain (Osadchiy et al., 2019)

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systematically examined food-derived peptides with anti-IBD properties, analyzing their amino acid sequences, physicochemical characteristics, and biological mechanisms

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