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It reduces appetite, slows gastric emptying, and improves blood sugar control

doi:10.1016/j.plefa.2009.04.009 Sandor B, Papp J, Mozsik G, et al

Comparison with CRH-induced corticotropin and cortisol secretion

Investigation of the adrenergic and opioid binding affinities, metabolic stability, plasma protein binding properties, and functional effects of selected indole-based kratom alkaloids