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Safety Toxicity A number of possible problems with very large doses of vitamin C have been suggested, mainly based on in vitro experiments or isolated case reports, including genetic mutations, birth defects, cancer, atherosclerosis, kidney stones, "rebound scurvy," increased oxidative stress, excess iron absorption, vitamin B12 deficiency, and erosion of dental enamel

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These results suggest that astrocytic SNAT-3 loss alters neurotransmitter balance without inducing overt depressive-like behaviors

11, 14898 (2021), Abstract ABCE1 Regulates RNase L-Induced Autophagy during ViralInfections: B