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The study demonstrated that cynaroside exhibited no significant toxic side effects while improving glucose-lipid metabolism disorders in obese mice, reducing inflammatory responses, enhancing gut microbiota diversity, and stabilizing the intestinal microbial balance (Yang et al., 2025)

Upon injury, the injured nerves quickly undergo Wallerian degeneration characterized by dedifferentiation of mature Schwann cells into a repair phenotype with increased phagocytic, migratory, and secretory functions, followed by the recruitment of macrophages to aid the clearance of axonal and myelin debris [2, 4, 5]