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Inhibiting glutamine pathway, including downregulating glutamine transporter ASCT2 [84] or inhibit glutaminase by CB-839 [85] can deplete intracellular GSH, but such effect of CB-839 was only observed in cancer cell lines expressing xCT supplied with high cystine in the culture [86]

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Cisplatin induces endoplasmic reticulum stress and nucleus-independent apoptotic signaling

Studies suggest this derivative may address both extrinsic photoaging and intrinsic hyperpigmentation without the formulation challenges of parent compound ascorbic acid

Lipoic acid mitigates oxidative stress and recovers metabolic distortions in salt-stressed wheat seedlings by modulating ion homeostasis, the osmo-regulator level and antioxidant system