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Glycocalyx function Regulating vascular permeability Notably, glycocalyx degradation exacerbates vascular permeability by disrupting VE-cadherin and occludin [41], while intact glycocalyx suppresses MMP-9-mediated inflammation [42, 43]

This indicates that PRNP may function as an important gene modifier in WD 21 , and the Cu-binding and transporting properties of WD-modulating variants of PrP warrant further investigation