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Specific amino acids within the IGF-1 molecule have been shown by site-directed mutagenesis to account for receptor and/or binding protein association (Table 24-1)

Cancer 124, 16231636

The use of different moieties has been extensively discussed in other works and goes beyond the scope of the present paper (Blanco et al., 2015)

Knockdown of BCAT1 causes accumulation of -KG, promoting EGLN1-mediated HIF1 protein degradation and leukemia-initiating arrest (Raffel et al., 2017)

Conclusion Ipamorelin and CJC-1295 represent two of the most pharmacologically well-characterised GH secretagogue peptides available for research use, with complementary receptor mechanisms that make them particularly valuable as paired tools for investigating the hypothalamic-pituitary GH axis