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The finding that 5 of 11 vitamin B 12 deficiency patients without a history of gastrectomy complained of tongue pain in the absence of any significant pathologic oral signs suggests that blood examinations, including vitamin B 12 measurements, are mandatory for patients with glossodynia

Animal and in vitro studies provide support and are used mainly to supply evidence missing from human studies

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doi: 10.1097/YIC.0000000000000130 190