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Studies demonstrate rapid systemic uptake and targeted activity at endothelial and fibroblastic levels, implicating it in nitric oxide modulation, collagen synthesis, and vascular repair

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Based on the positive results from three Phase III studies, in 2012 FDA approved topiramate/phentermine extended-release as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in eligible adults

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Among its various functions, the role as immunomodulator in cellular immunity, especially in elevating the number of CD8+ cells and NK cells, attracts scientific interest

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