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Both in vitro and in vivo studies have shown that inflammatory factors such as IL-1 and TNF- upregulate the expression of ASIC1a, which promotes chondrocyte apoptosis, as demonstrated in both a rat adjuvant arthritis model and a primary articular chondrocyte model

doi: 10.1007/s00253-009-1893-z 411 TianL.HiresS

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Cigarette smoke and nicotine constrict the blood vessels and mucous membranes in the mouth

GIP activation works synergistically with GLP-1 to enhance insulin secretion and may play an independent role in fat metabolism