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Starting with high doses (1,000 mcg to 2,000 mcg) weekly or biweekly is common

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If the kidneys are already under strain (which is common with age, diabetes, or high blood pressure), this direct load can be too much to handle

American Association of Clinical Endocrinologists and American College of Endocrinology comprehensive clinical practice guidelines for medical care of patients with obesity

clear instructions, works great I asked for a slightly smaller needle , like a 28 gauge, or tb size, but I got no answer about getting those instead I felt energized after two dosages Great product Great price and works great