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These data imply a critical link between the p38 MAPK/STAT6 pathway and ferroptosis-mediated VEGFA and IL8 expression in ESCs

NF-kappaB activation is a critical regulator of human granulocyte apoptosis in vitro J Biol Chem 1999 274 : 43094318 von Knethen A, Callsen D, Brune B

Nevertheless, caution should be exercised, as cases of uterine rupture associated with castor oil ingestion have been reported in the literature (Sicuranza and Figueroa, 2003