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Important Safety Information Contraindications and Precautions: Joint injections should only be performed by qualified medical professionals Active joint infection is an absolute contraindication to intra-articular injection Bleeding disorders or anticoagulation therapy may increase injection risks Pregnancy and breastfeeding: no safety data available, avoid use Cancer history: while AOD-9604 does not affect IGF-1, consult oncologist before use Monitoring Recommendations: Regular follow-up with joint imaging and functional assessments to evaluate treatment response

doi: 10.1104/pp.126.4.1646 70 MarcecM

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A polynucleotide encoding a polypeptide of the present invention is amplified using PCR oligonucleotide primers corresponding to the 5 and 3 ends of the DNA sequence, as outlined in Example 18, to synthesize insertion fragments