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6 compares the binding mode of atorvastatin to HMG-CoA-R 34 and RyR1

Coenzyme Q10 as a therapy for mitochondrial disease

J Clin Med (2023) 12(5):1858

Sci., 2022, 9, 2106049 CrossRef CAS PubMed

Taken together, these findings emphasize that target selection is ultimately a systems-level decision, where integrating molecular evidence, disease-class specificity, expression context, and historical maturity provides a more robust framework than relying on any single metric alone