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Abbreviations 4-HNE: 4hydroxy nonenal 5-FU: 5Flourouracil 8-isoPGF: 8isoProstaglandin F2 8-NG: 8Nitroguanine 8-OHdG: 8hydroxy2deoxyguanosine AA: Ascorbic acid ABM: Abamectin ALC: AcetylLcarnitine ARE: Antioxidant response element ASM: Antiseizure medications CAT: Catalase CBZ: Carbamazepine CIS: Cisplatin CRE: cAMP response element CS: Chondroitin sulphate DHEA: Dehydroepiandrosterone DZP: Diazepam FA: Ferulic acid FRAP: Ferric reducing ability of plasma FRDA: Friedreichs ataxia GPx: Glutathione peroxidase GSH: Reduced glutathione GSSG: Glutathione disulphide GST: Glutathione S transferase HDM: House dust mite HO-1: Heme oxygenase1 ILF: Idiopathic lung fibrosis IMI: Imidacloprid iNOS: Induced nitric oxide synthase LCM: Lacosamide LEV: Levetiracetam LicA: Licochalcone A LPS: Lipopolysaccharide MAPK: Mitogen activated protein kinase MDA: Malondialdehyde MEK: Mitogen activated protein kinase kinase MOE: Melissa officinalis extract NDMA: Nitrosodimethylamine NF-B: Nuclear factor kappalightchainenhancer of activated B cells nNOS: Neuronal nitric oxide synthase NO: Nitric oxide NQO-1: NAD(P)H: quinone oxidoreductase 1 NRF2: Nuclear factor erythroid 2related factor 2 OSHE: Ocimum sanctum hydroalcoholic extract PB: Phenobarbital PC: Protein carbonyl PCL: Polycaprolactone PGC-1: Peroxisome proliferatoractivated receptor gamma coactivator 1alpha PHT: Phenytoin P-JNK: Phosphorylated cJun kinase PTX: Pentoxifylline PTZ: Pentylenetetrazol ROS: Radical oxygen species SIRT1: Sirtuin 1 SOD: Superoxide dismutase STAT3: Signal transducer and activator of transcription 3 TAC: Total antioxidant capacity TLR4: Tolllike receptor 4 TNF: Tumor necrosis factor TPM: Topiramate VPA: Valproate References World Health Organization (2019) EPILEPSY A public health imperative

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Laskaris et al., 2016