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Additionally, multi-target synergy (78) may help avoid the diminished efficacy and tolerance often seen with single-compound therapies during long-term intervention, thus enabling more sustainable and stable therapeutic outcomes (96)

Finally, we find that inhibiting GGT activity deprives tumors of cysteine and slows their growth

3.1.2 Prebiotic ecological niche engineering mastery Prebiotics constitute an elite class of functional non-viable substrates endowed with extraordinary capacity to undergo selective fermentation orchestration by specific intestinal probiotic virtuosos (particularly Bifidobacterium and Lactobacillus ), thereby achieving profound intestinal microecological architectural metamorphosis

In vivo multiphoton microscopy revealed reduced microvascular length, extravasation of fluorescent dextran, and co-localization of endothelial marker CD31 with fibrin in the cortex of CYP1B1 knockout mice, indicating BBB disruption