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The ensuing phagocytosis of RBCs may lead to iron overload within macrophages, which has been shown to cause progressive macrophage dysfunction, inflammatory M1 polarization, increased ferroptosis and exacerbated atherosclerosis 66,67,68,69,70,71

Multiple sequence alignment of over 100 known G6PDs from different organisms reveal sequence identity ranging from 30% to 94%

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