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If storage-driven surface changes reduce early biological performance, then a clinically deployable method to restore surface bioactivity immediately before use could be valuable

Local administration of transcription factor decoy oligonucleotides to nuclear factor-kappaB prevents carrageenin-induced inflammation in rat hind paw Gene Ther 2000 7 : 17311737 Gerbes AL, Vollmar AM, Kiemer AK, Bilzer M

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Preclinical models may be utilized to evaluate the efficiency of prospective therapies or procedures, acknowledging that the significance of harm and protective pathways, along with the administration of therapy, may vary between the preclinical model and people