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Winter S, Rehm A, Wichner K, Scheel T, Batra A, Siegmund B, et al

Over 150 mutations in the SOD1 gene have been described to cause amyotrophic lateral sclerosis (ALS) a fatal neurodegenerative disease that affects the upper and lower motor neurons 6,7 in an autosomal dominant fashion, accounting for about 20% of the familial cases of ALS (fALS) 8,9