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In addition to conventional chemotherapeutics (e.g., doxorubicin, cisplatin, oxaliplatin, and 5-fluorouracil), targeted therapy drugs include kinase inhibitors (e.g., sorafenib, regorafenib, lenvatinib, and cabozantinib), immune checkpoint inhibitors (e.g., pembrolizumab, atezolizumab, and nivolumab), and angiogenesis inhibitors (e.g., ramucirumab and bevacizumab) and are currently used for systemic therapy in patients with HCC

6 Given this high prevalence of B 12 deficiency in elderly population, it would seem intuitive that many patients with DCM are also affected

Transplantation of mitochondria isolated from young, healthy donors into aged animal models has been shown to alleviate anxiety-like behaviors, improve synaptic plasticity, and restore bioenergetic capacity in the brain [100, 101]

(11-13) Bioactive 5-MTHF folate Two-Per-Day formula contains 5-methyltetrahydrofolate (5-MTHF), a form of folate that is up to seven times more bioavailable than folic acid