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Cells 8(8):80 Kuo TC, Chen CK, Hua KT et al (2016) Glutaminase 2 stabilizes Dicer to repress Snail and metastasis in hepatocellular carcinoma cells

Work in poultry showed that XOS supplementation increased the conversion of lactate to butyrate [186]

Anti-Inflammatory and Antioxidant Effects: The compound reduces NF-B activation and inflammatory cytokines (up to 60% reduction in some studies), decreases oxidative stress markers, protects against UV-induced damage, and modulates inflammatory responses

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Therefore, in states of chronic under-nutrition, hepatic GH resistance is an adaptive response, as high GH levels are necessary to maintain euglycemia, while low IGF-I levels conserves energy during periods of nutritional deprivation