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Early small trials suggested that TUDCA might slow functional decline in ALS patients, leading to larger studies.38 TUDCA was later tested in combination with sodium phenylbutyrate (marketed as Relyvrio/AMX0035)

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Acetylation of C/EBP, to illustrate, impairs its ability to bind to DNA and affects recruitment to C/EBP target genes (such as the G-CSF receptor), inhibiting granulocyte differentiation