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Consisting of dimeric transcription factors such as Jun and Fos, AP-1 binds to DNA motifs, such as TPA-responsive element (TRE) and cAMP-responsive element (CRE), initiating transcription of genes critical for cell survival and stress adaptation 73,74

After blocking with 5% nonfat dry milk in TBS-Tween for 12 h at room temperature, blots were incubated with appropriate primary antibodies overnight at 4 C

Recommended Usage 1-6 lozenges daily as instructed by Nutritionist / dietician.

In particular, Trastuzumab emtansine (Kadcyla, T-DM1) that comprises an HER2-targeted antibody, a non-cleavable linker and a microtubule disrupting agent as the payload, and Trastuzumab deruxtecan (Enhertu, T-DXd), which is composed of a HER2-targeted antibody, a cleavable linker and a Topoisomerase I inhibitor as payload