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Quick answer is yes there is a difference and yes Undenatured is better

Water (Aqua), 5% GHK-Cu (Copper), 3% Acetyl hexapeptide-8 (Argireline), Snail Secretion Filtrate, Glycerin, Panthenol (Pro-Vitamin B5), 2% Niacinamide (B3), Phenoxyethanol (Preservative), 1% Sodium Hyaluronate (Hyaluronic Acid), Organic Aloe Barbadensis Leaf (Aloe) Extract, Rosa Damascena Flower (Rose) Water, Ethylhexylglycerin (Preservative), Cucumis Sativus (Organic Cucumber) Fruit Extract, Chamomilla Recutita (Organic Matricaria) Flower Extract, Carica Papaya (Organic Papaya) Fruit Extract, Oryza Sativa (Organic Rice) Extract, Sodium Phytate

doi:10.1021/acsbiomaterials.6b00140 146

sativum extract may be due to several factors: (a) triterpenoidal saponins interacting with glomerular membrane components, influencing fluid filtration