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Author contributions Akeem Adeyemi Oladipo: conceptualization, data curation, writing review & editing, writing original draft, visualization.Conflicts of interest There are no conflicts to declare.Abbreviation AOPAdverse outcome pathway As(V)Arsenate CNTsCarbon nanotubes Cr(VI)Hexavalent chromium DLVODerjaguinLandauVerweyOverbeek DOMDissolved organic matter EC50Median effective concentration ENMsEngineered nanomaterials GOGraphene oxide HTSHigh-throughput screening LCALifecycle assessment MCDAMulti-criteria decision analysis MIEsMolecular initiating events NNPsNatural nanoparticles NOECNo-observed-effect concentration NOMNatural organic matter nZVINanoscale zero-valent iron PAHsPolycyclic aromatic hydrocarbons PCBsPolychlorinated biphenyls PECsPredicted environmental concentrations POPsPersistent organic pollutants QSARQuantitative structureactivity relationship rGOReduced graphene oxide ROSReactive oxygen species SbDSafer-by-design sp-ICP-MSSingle-particle inductively coupled plasma-mass spectrometry TCETrichloroethylene TiO2Titanium dioxide ZnOZinc oxide 8-OHdG8-Hydroxy-2-deoxyguanosine Data availability No new data were created or analyzed in this study