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76 Based on the screening of the first CovLib subset, our group identified multiple S N Ar reactive covalent p53-Y220C cleft binders, among them, the highly reactive tyrosine mimicking pyridine derivative SN001 and the pyrazine derivative SN006/7-8 stabilizing the protein up to 4.5 C and 5.0 C, respectively

Statistical analysis Data were analyzed using two-way analysis of variance followed by the Tukey test

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