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In addition, ascorbate has the capacity to reduce free redox-active transition metal ions, such as copper and iron

In diabetes, persistent hyperglycemia and mitochondrial dysfunction lead to elevated ROS production, intensifying OS [149]

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Indeed, recent work uncovered a novel transcription-coupled pathway of formaldehyde-induced DNA-protein crosslinks (DPCs), which depends on CSB but not downstream NER factors 57,58,59