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While models of NF1-OPG are highly variable in their presentation, improving upon the current models by varying the cell of origin [217] or genetic mutation [218, 219], as well as developing NF1-OPG models in different species, like pigs [220], to study RGC replacement may enable these therapies to enter the clinic with fewer regulatory hurdles if given an orphan disease designation

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The predicted structures of PI3K were generated by Alphafold (DeepMind Technologies, London, UK)