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We compared islet cell distributions and determined graded intensities of glutathione peroxidase1 (GPX1), a key enzymatic mediator involved in detoxifying hydrogen peroxide, by applying combined immunohistochemistry for GPX1, insulin and glucagon, in pancreatic sections from new-onset T1D (group 1), non-diabetic autoantibody-negative (group 2), non-diabetic autoantibody-positive (group 3) and long-term diabetic (group 4) donors

It is hypothesized that this increase may correspond to a rise in fat pad weight relative to overall body mass, as suggested by DEXA scans, which appear to show a rise in body fat percentage

In contrast, Fp GUS and Bd GUS were inhibited at pH 7.5 but did not show an inhibition of 80% or greater at pH 6.5 (Fig

doi: 10.1212/NXI.0000000000001125 97 SunCYuWZhaoZSongCLiuYJiaGet al