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To this end, the development of new therapies, ideally targeting synovitis and inflammatory-related bone erosion in joints, as well as regulating those inflammation-independent factors that can also interfere with bone homeostasis in RA, such as the general RANKL signaling pathway, would be promising for remodeling bone homeostasis in RA

(179) demonstrated that in rat models of NASH, HUC-MSCs exosomes enhanced the Nrf2 (Nuclear factor erythroid 2-related factor 2), a protective factor against oxidative stress and 1 [NAD (P) H quinone dehydrogenase 1], a part of cellular adaptive response to stress, which seems to play a significant part in treating NASH (180)

-Glucuronidase, a representative microbial enzyme secreted by gut bacteria, catalyzes the hydrolysis of glucuronide conjugates and xenobiotic detoxification processes

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10.1016/j.ibneur.2023.11.002 100 Mar-BausetS.Llopis-GonzlezA.Zazpe-GarcaI.Mar-SanchisA.Morales-Surez-VarelaM