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Fibrotic encapsulation of silicone implants used in aesthetic or reconstructive medicine (e.g., mammoplasty, rhinoplasty) represents another important medical need

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One suggestion of the metabolic substrate these cells can provide comes from the lactate shuttle hypothesis, which proposes that glial cells like astrocytes and Mller glia can uptake glucose and convert it to lactate to provide a metabolic substrate to RGCs (Hurley et al., 2015)