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Guzman, Atsushi Nakano, Elena G

This microglia produces chronic inflammatory mediators associated with neuroinflammation and parainflammation

HIV-1 transgene expression in rats causes oxidant stress and alveolar epithelial barrier dysfunction

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Recently, specific inhibitors of ACSL4 and research on its upstream transcriptional regulators such as SP1 have shown clear cartilage-protective effects in OA models, suggesting that future strategies combining GPX4 modulation to enhance defense with ACSL4 inhibition to reduce attack may achieve more potent and synergistic therapeutic outcomes (He W