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After the discovery of diphenylhydantoin as a chemical drug for seizures in 1938, the attention of physicians and researchers shifted from KD to the new anti-epileptic drug

Other top cancer drugs include Bristol-Myers Opdivo (nivolumab, ~$9.0 B) and Johnson & Johnsons Darzalex (daratumumab, ~$11.6 B

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Intriguingly, the proinflammatory cytokine IL-23 has been identified as a stimulant for CDK7 expression in CD4+ T cells, further amplifying glycolytic activity through activation of the PKB/mTOR/HIF-1 signaling network in a psoriasis-like mouse model induced by imiquimod (IMQ) (19)