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Disruption of GSH production can impair tumorigenesis 17,18,19 , but the exact mechanisms involved are unclear

In vivo studies using mice lacking a component of the base excision repair process revealed significant stomach lesions after H pylori infection (46)

showed that, in a microenvironment deprived of glutamine, due to glutamine addiction in clear cell renal cell carcinoma (ccRCC), tumor-associated macrophages (TAMs) promote an immunosuppressive microenvironment [154]