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In patients with Leber's disease, administration of cyanocobalamin may cause acute and rapid atrophy of the optic nerve

Conclusion In summary, the choice between Bacteriostatic Water and Sterile Water hinges on the specific medical application, required preservative use, and the nature of the medication involved

There are no other absolute contraindications reported for hydroxocobalamin use in deficiency states, but caution is advised in individuals with conditions such as early Lebers optic neuropathy (a rare hereditary optic atrophy) due to the theoretical risk of worsening vision

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Perhaps they were imprecise and unsuccessful