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Metformin, a well-known first-line drug for diabetes treatment, was found to be capable of down-regulating CSC marker CD44 in primary oral cancer cells [102]

Pang JH, Wu YH, Cheng CY (2019) Quercetin inhibits the production of IL-1-induced inflammatory cytokines and chemokines in ARPE-19 cells via the MAPK and NF-B signaling pathways

Sena CM, Pereira AM, Seica R (2013) Endothelial dysfunctiona major mediator of diabetic vascular disease

It appears on the outside of cells in only a few places

The effects as they relate to various body systems are described as follows: **General and cellular actions** Caffeine exerts several actions on cells, but the clinical relevance is poorly understood