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Colony formation assays indicated that colonies formed by the IDH1 WT/Mut group were smaller than those of the IDH1 WT/WT group, suggesting that the IDH1-R132H mutation significantly inhibits tubular epithelial cell proliferation (Fig

Biology (Basel) 10 , 2

175,176 STATs are phosphorylated and translocated into the nuclear compartment to transcriptionally upregulate specific genes, 177 often leading to cell proliferation or differentiation

Several clinical trials have focused on encapsulating and delivering chemotherapeutics in nanoparticles for the treatment of brain tumors and metastases (9)

Pharmacological treatments are the most widely available and have the greatest variety of options and a number of novel pharmacological treatments are presented as highlights, including JAK enzyme inhibitors